ROeS Seminar 2009

Program – ROeS 2009 in Linz

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• ROeS Program and Abstract Booklet (1MB, ROeS_Program_and_ AbstractBooklet.pdf)

Sunday 13.9.

afternoon (14:00-18:00)

Bayesian Statistics - Pre-Seminar course (Part I)

Lecturers: Beat Neuenschwander, Michael Branson (Basel, CH)

Monday 14.9.

morning (9:00-12:30)

Bayesian Statistics - Pre-Seminar course (Part II)

Lecturers: Beat Neuenschwander, Michael Branson (Basel, CH)

afternoon

14:00 - 14:20 Welcome address

Martina Mittlböck (ROeS President, Vienna, A)

Gabriele Kotsis (Vice Rector for Research JKU, Linz, A)

Helga Wagner (Local Organizer, Linz, A)

14:20 - 17:00 Time to Event Data: Advanced Methodologies in Clinical Practice

Chairs: Mike Branson, Markus Abt (Basel, CH)

14:20 - 15:10 T. Therneau (Mayo Clinic, USA): Random Effects Models and Survival Data

15:10 - 15:40 B. Neuenschwander (Basel, CH) : Evidence Synthesis of Adverse Event Data

15:40-16:00 Break

16:00 - 16:30 M. C. Småstuen (Oslo, Norway): Fitting of Proportion Cured Models – an Extensive Evaluation on a Large Data Set of Several Cancer Sites

16:30 - 17:00 A. Sashegyi (Indianapolis, USA): Practical Issues in the Definition and Analysis of Endpoints in CV Clinical Trials

18:00 Guided Tour through Linz

Tuesday 15.9.

morning

9:00 - 11:50 Early development in Oncology

Chairs: Michael Murawsky, Hans Ulrich Burger (Basel, CH)

9:00 - 9:10 H. U. Burger, M. Murawsky (Basel, CH): Introduction: Need for New Development Strategies in Oncology

9:10 - 9:50 S. Bailey (Basel, CH): Determining the optimal dosing strategies in oncology phase I dose-escalation

9:50 - 10:30 S.-F. Hsu Schmitz (Bern, CH): Design and Analysis of Early-Phase Clinical Trials with Intra-Patient Dose Escalation

10:30-10:50 Break

10:50 - 11:20 S. Mu (Nutley, USA): Mathematical Description of Longitudinal Tumor Growth and Response to Chemotherapy: Application in Dose Regimen Selection

11:20 - 11:50 W. Brannath (Vienna, A): On the Feasibility of Phase II/III Studies for Dose Finding in Oncology

9:00 - 11:20 Free Papers

Chair: Hanno Ulmer (Innsbruck, A)

9:00 - 9:30 T. Jaki (Lancaster, UK): Direct Effects Testing: A Two-Stage Method for Stepwise Testing for Effect Size and Variable Importance for Correlated 2x2 Tables

9:30 - 10:00 S. Stampf (Freiburg, D): Estimators and their Variances for Marginal Odds Ratios Based on Logistic Regression and Stratification by Propensity Score

10:00 - 10:30 M. Vock (Bern, CH): A Test for Perfect Ranking in Ranked Set Sampling

10:30-10:50 Break

10:50 - 11:20 A. Wöhrer (Vienna, A): ABTR – A Novel Population-Based Brain Tumour Registry for Austria

11.50 - 12:45 Mitgliederversammlung / ROeS member assembly

12.45 - 14:00 Lunch Break

afternoon

14:00 - 17:00 Free papers

Chair: Shu-Fang Hsu Schmitz (Bern, CH)

14:00 - 14:25 M.J. Wolfsegger (Vienna, A): Assessing Systemic Drug Exposure in Repeated Dose Toxicity Studies in the Case of Complete and Incomplete Sampling

14:25 - 14:50 C.U. Kunz (Heidelberg, D): Two-Stage Designs with Two Binary Endpoints in Phase II Cancer Trials

14:50 - 15:15 M. Posch (Vienna, A): Type I Error Rate Control in Adaptive Designs for Confirmatory Clinical Trials with Treatment Selection at Interim

15:15-15:45 Break

15:45 - 16:10 G. Mészáros (Vienna, A): Survival Kit 6.0: Software designed to deal with complex models including random effects in survival analysis

16:10 - 16:35 D. Volz (Basel, CH): A Simulation Study on Hazard Ratio and P-Value Dependencies at Stratification

16:35 - 17:00 C. Eulenburg (Hamburg-Eppendorf, D): Estimating the Impact of Progression on Survival in Ovarian Cancer Patients with a Parsimonious Multistate Model

14:00 - 17:00 Young Statisticians (I)

Chair: Andrea Berghold (Graz, A)

14:00 - 14:25 J. Zyprych (Poznań, Poland): The Methods of Analysis in cDNA Microarray Experiments

14:25 - 14:50 A. Łacka (Poznan, Poland): Planning of Factorial Experiments with One Control Treatment Dealing with Plant Protection in a Block Design with Nested Rows and Columns

14:50 - 15:15 S. Wakounig (Vienna, A): Nonparametric Estimation of Relative Risk in Survival and Associated Tests

15:15-15:45 Break

15:45 - 16:10 H. Kazianka (Klagenfurt, A): Classification of Hyper-Spectral Skin Data

16:10 - 16:35 I. Baldi (Torino; I): Prior Elicitation in Early Phase Clinical Trials

16:35 - 17:00 T. Jaki (Lancaster, UK): One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint

evening

17:00 Poster presentation

17:00 - 17:40 STATA Software presentation

18:00 Buffet

Wednesday 16.9.

morning

9:00 - 11:20 Bayesian Statistics

Chair: Sylvia Frühwirth-Schnatter (Linz, A)

9:00 - 9:50 K. Ickstadt (Dortmund, D): Bayesian Nonparametric Estimation of Monotone Functions

9:50-10:05 Break

10:05 - 10:30 M. Dvorzak (Graz, A): Bayesian Estimation of a Beta-Poisson Model

10:30 - 10:55 H. Wagner (Linz, A): Identifying Risk Factors for Complications after ERCP by Bayesian Variable Selection

10:55 - 11:20 P. Müller (Houston, USA): A Bayesian Subgroup Analysis with a Zero-Enriched Polya Urn Scheme

9:00 - 11:20 Free papers

Chairs: Barbara Schneider, Wolfgang Wertz (Vienna, A)

9:00 - 9:25 W. Wertz (Vienna, A): Fractal Models in Biology

9:25 - 9:50 I. Stelzer (Vienna, A): The Fractal Structure of Tumors and Tumor Cells

9:50-10:05 Break

10:05 - 10:30 Ch. Krall (Vienna, A): A Model of Multivariate Evolution

10:30 - 10:55 F. Frommlet (Vienna, A): Tag SNP Selection Based on Clustering with Domi-nant Sets and the Replicator Dynamic

10:55 - 11:20 G. Rauch (Heidelberg, D): The LORELIA Residual Test – A New Outlier Identification Test for Method Comparison Studies

11:20 - 12:40 Lunch Break

afternoon

12:40 - 15:00 Risk-assessment

Chair: Hans-Peter Stüger (Graz, A)

12:40 - 13:30 M. Greiner (Berlin, D): Model-Based Analysis of Risk-Based Surveillance Data: Estimation of BSE Prevalence in the German Cattle Population

13:30-13:45 Break

13:45 - 14:10 K. Kepplinger (Graz, A): Aspects of Risk-Based Sampling in the Official Food Control Plan of Austria

14:10 - 14:35 J. Hofrichter (Graz, A): Risk Assessment of Bluetongue Occurrence in Austria

14:35 - 15:00 M. Stehlik (Linz, A): Homogeneity Testing for Risk Assessment in Medical Diagnostics

12:40 - 15:00 Free papers: Genetics

Chair: Karl-Peter Pfeiffer (Innsbruck, A)

12:40 - 13:05 D. Dunkler (Vienna, A): Gene Selection with Microarray Survival Data under Non-Proportionality

13:05 - 13:30 K. W. Wittkowski (New York, USA): Hierarchical Factor Structures Enable U-Scores for Multivariate Censored and Graded Data

13:30-13:45 Break

13:45 - 14:10 J. Sölkner (Vienna,A): A Comparison of Different Methods of Utilizing SNP Information in Genome Wide Selection of Dairy Cattle

14:10 - 14:35 F.A. Pedross (Innsbruck, A): Kernel Discrimination with Different Bandwidth Matrices Applied in Microarray Analysis

14:35 - 15:00 F. Klinglmüller (Vienna, A): Best Practices for Microarray Data – Some Results from Recent Technology Validation Attempts

15:15 Excursion and Dinner

Excursion to the Monastery St. Florian and Conference Dinner in St. Florian

Thursday 17.9.

morning

9:00 - 11:25 Medical Research and genetic information: new challenges for data analysis

Chairs: Martin Posch (Vienna), Andreas Krause (Basel)

9:00 - 9:50 A. Ziegler (Lübeck, D): Statistical Aspects of Genome-Wide Association Studies

9:50 - 9:15 Y. Bauer (Basel, CH): Gene Expression Analysis of Doxorubicin-Induced Cardiotoxicity in Rats

10:15-10:35 Break

10:35 - 11:00 E. Zuber (Basel, CH): Adaptive Subpopulation Selection: a Development Strategy for a Targeted Agent in Oncology

11:00 - 11:25 A. Futschik (Vienna, A): Statistical Approaches to Search for Candidate Regions Involving Quantitative Traits

11:25 - 11:55 Arthur-Lindner-Award

11:55 - 12:20 Lunch Break

afternoon

12:20 - 14:00 Free papers

Chair: Karl Moder (Vienna, A)

12:20 - 12:45 A. Graf (Vienna, A): Model Selection Based on FDR-Thresholding Optimizing the Area under the Receiver Operating Characteristic Curve

12:45 - 13:10 S. Zehetmayer (Vienna, A): Post-Hoc Power Estimation in Large-Scale Multiple Testing Problems

13:10 - 13:35 M. Mayer (Bern, CH): Asymptotic Normality of U-Quantile-Statistics

13:35 - 14:00 T. Grubinger (Innsbruck, A): Diverse and Accurate Regression Tree Models as Candidates for the Austrian DRG-system

12:20 - 14:00 Young Statisticians

Chair: M. Vandemeulebroecke (Basel, CH)

12:20 - 12:45 J. Braun (Zürich, CH): A Predictive Cross Validation Approach for Selecting Linear Mixed-Effects Models for Continuous Longitudinal Data

12:45 - 13:10 M. Trampisch (Bochum, D): Assessing the Similarity of Two Dose Response Curves

13:10 - 13:35 M. Akacha (Warwick, UK): The Impact of Dropouts on the Analysis of Dose-Finding Studies with Recurrent Event Data

13:35 - 14:00 P. Sekula (Freiburg, D): Risk Assessment Based on Case Series – the Case-Crossover Method

14:00 - 14:15 Closing Ceremony